Role of RBPJk in Notch Dependent Signalling in Early Embryonic Development of Mice

Notch signalling is an intercellular signalling mechanism that belongs to a family of four highly conserved transmembrane proteins. Its core transcriptional regulator RBPJ_k serves as a molecular centre for interactions with corepressor or coactivators, which inhibit or promote transcription, respectively. It is the main protein that control the expression of the target proteins involved in cell fate decisions by mediating signalling from Notch. Notch signalling pathway is an evolutionarily conserved signalling system that has been proven to be crucial for cell fate specification and embryonic development of all metazoans. Therefore, mutations or complete loss-of-function of Notch, RBPJ_k, and associated genes may effects on embryonic development or sometimes also results in embryonic death. In the present study, we reviewed the previous literatures for the better understanding of the RBPJ_k dependant notch signalling role in the embryonic development of the mice.

@article{krishnakshi2026,
  author  = {Krishnakshi Misra* and H.N. Sarma},
  title   = {{Role of RBPJk in Notch Dependent Signalling in Early Embryonic Development of Mice}},
  journal = {Journal of Bioresearch},
  year    = {2026},
  volume  = {3},
  number  = {1},
  pages   = {14-24},
  doi     = {https://doi.org/10.56716/4/2320},
}